Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9469283 | 0.87 | ALDH1A1 (0.39) | MAPTGAAALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL9469385 | 0.87 | GAA (0.39) | MAPTKAT2BGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL4690229 | 0.87 | ALDH1A1 (0.34) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL9470368 | 0.85 | ALDH1A1 (0.43) | MAPTKAT2BGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL9470503 | 0.82 | ALDH1A1 (0.40) | MAPTGAAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL9470466 | 0.82 | KMT2A (0.47) | MAPTGAAALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL9469535 | 0.79 | ALDH1A1 (0.50) | MAPTGAAALDH1A1CYP1A2ALKBH5 | |
| SCHEMBL9470341 | 0.78 | MEN1 (0.40) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL9470196 | 0.78 | ALDH1A1 (0.39) | MAPTGAAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL9470115 | 0.75 | ALDH1A1 (0.45) | MAPTKAT2BGAAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5182289-A | Pyrrolo 2,3-b!Pyridin-2-one Derivatives | SCHERING CORPORATION (US) | 1993-01-26 | — | — | US | claimed |
| EP-0419561-A1 | HETEROBICYCLIC COMPOUNDS HAVING ANTIINFLAMMATORY ACTIVITY | SCHERING CORPORATION (US) | 1991-04-03 | — | — | EP | claimed |
| WO-1989012637-A1 | HETEROBICYCLIC COMPOUNDS HAVING ANTIINFLAMMATORY ACTIVITY | SCHERING CORPORATION (US) | 1989-12-28 | — | — | WO | claimed |