Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1170858 | 0.73 | PRKCA (0.42) | PRKCA | |
| SCHEMBL10417600 | 0.73 | PRKCA (0.42) | PRKCA | |
| SCHEMBL3829696 | 0.72 | ELANE (0.41) | CYP4F2CYP4A11 | |
| SCHEMBL11047853 | 0.71 | TSHR (0.31) | — | |
| SCHEMBL16730738 | 0.71 | TSHR (0.37) | CYP4F2CYP4A11PRKCA | |
| SCHEMBL11446926 | 0.71 | — | — | |
| SCHEMBL15219616 | 0.71 | CTSK (0.32) | CYP4F2CYP4A11 | |
| SCHEMBL11475136 | 0.70 | CYP4F2 (0.38) | CYP4F2CYP4A11 | |
| SCHEMBL25258063 | 0.70 | MEN1 (0.32) | — | |
| SCHEMBL26932887 | 0.70 | MMP8 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5192800-A | Hypotensive agents | PFIZER INC. (US) | 1993-03-09 | — | — | US | disclosed |
| EP-0274234-B1 | SPIRO-SUBSITUTED GLUTARAMIDE DIURETIC AGENTS | Pfizer Limited (GB) | 1991-09-11 | — | — | EP | disclosed |
| US-5030654-A | Glutaramide diuretic agents | PFIZER INC. (US) | 1991-07-09 | — | — | US | disclosed |
| EP-0274234-A2 | Spiro-subsituted glutaramide diuretic agents | Pfizer Limited (GB) | 1988-07-13 | — | — | EP | disclosed |