SCHEMBL9469656

SCHEMBL9469656

CC(C)(C)OC(=O)Nc1ccc(Cl)cc1C1Cc2ccccc2N1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 1/20 0.45
HSP90AA1 P07900 1/20 0.40
HSP90AB1 P08238 1/20 0.40
CDK1 P06493 1/20 0.39
EGFR P00533 1/20 0.37
SRC P12931 1/20 0.37
RXFP1 Q9HBX9 1/20 0.36
AR P10275 1/20 0.36
BRD4 O60885 2/20 0.36
CREBBP Q92793 2/20 0.36
SIRT2 Q8IXJ6 1/20 0.35
SIRT1 Q96EB6 1/20 0.35
FNTA P49354 1/20 0.35
FNTB P49356 1/20 0.35
KDM4E B2RXH2 1/20 0.35
IDO1 P14902 1/20 0.35
GAA P10253 1/20 0.35
MAPT P10636 1/20 0.35
TAS1R3 Q7RTX0 1/20 0.35
TAS1R1 Q7RTX1 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9469019 0.87 RAB9A (0.46) ARKDM4EGAAMAPTTAS1R3
SCHEMBL9469366 0.79 AR (0.44) ARKDM4EGAAMAPT
SCHEMBL29840277 0.77 USP30 (0.43) HSP90AA1HSP90AB1BRD4CREBBPSIRT2
SCHEMBL9469934 0.76 AR (0.43) EPHX2EGFRARBRD4CREBBP
SCHEMBL9469154 0.72 CETP (0.43) EPHX2ARKDM4EGAAMAPT
SCHEMBL3787046 0.72 KMT2A (0.54) HSP90AA1HSP90AB1IDO1GAAMAPT
SCHEMBL6628806 0.71 PDK1 (0.56) HSP90AA1HSP90AB1IDO1MAPT
SCHEMBL9469797 0.70 AR (0.47) ARKDM4EIDO1GAAMAPT
SCHEMBL4118124 0.70 LPAR1 (0.52) HSP90AA1HSP90AB1EGFRKDM4EGAA
SCHEMBL3327166 0.70 KCNMA1 (0.54) HSP90AA1HSP90AB1KDM4EGAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5166170-A 2-(AMINOARYL) INDOLES AND INDOLINES AS TOPICAL ANTIINFLAMMATORY AGENTS FOR THE TREATMENT OF SKIN DISORDERS HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1992-11-24 US claimed
US-5214059-A Dermatitis, psoriasis HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1993-05-25 US disclosed
US-5166170-A 2-(AMINOARYL) INDOLES AND INDOLINES AS TOPICAL ANTIINFLAMMATORY AGENTS FOR THE TREATMENT OF SKIN DISORDERS HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1992-11-24 US disclosed