Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | BCL6 | P41182 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9469995 | 0.86 | RAB9A (0.55) | DHODHKMT2AMEN1ALDH1A1RAB9A | |
| SCHEMBL1375014 | 0.82 | DHODH (0.56) | DHODHKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL5252795 | 0.82 | DHODH (0.51) | DHODHKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL1908379 | 0.82 | DHODH (0.56) | DHODHKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL3633702 | 0.78 | DHODH (0.51) | DHODHKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL9753940 | 0.78 | BRD4 (0.48) | DHODHKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL27975923 | 0.78 | DHODH (0.47) | DHODHKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL14604182 | 0.76 | DHODH (0.56) | DHODHKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL28045414 | 0.76 | GRM5 (0.37) | KMT2AMAPTALDH1A1GRM4RAB9A | |
| SCHEMBL16024049 | 0.76 | DHODH (0.56) | DHODHKMT2AMEN1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5182289-A | Pyrrolo 2,3-b!Pyridin-2-one Derivatives | SCHERING CORPORATION (US) | 1993-01-26 | — | — | US | disclosed |
| EP-0419561-A1 | HETEROBICYCLIC COMPOUNDS HAVING ANTIINFLAMMATORY ACTIVITY | SCHERING CORPORATION (US) | 1991-04-03 | — | — | EP | disclosed |
| WO-1989012637-A1 | HETEROBICYCLIC COMPOUNDS HAVING ANTIINFLAMMATORY ACTIVITY | SCHERING CORPORATION (US) | 1989-12-28 | — | — | WO | disclosed |
| EP-0347698-A1 | Heterobicyclic compounds having antiinflammatory activity | SCHERING CORPORATION (US) | 1989-12-27 | — | — | EP | disclosed |