Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9469355 | 0.90 | KMT2A (0.51) | BRD4DHODHKMT2AMAPTMEN1 | |
| SCHEMBL4690949 | 0.86 | GRM4 (0.45) | BRD4DHODHALDH1A1KMT2AMAPT | |
| SCHEMBL9754131 | 0.80 | DHODH (0.42) | BRD4DHODHALDH1A1KMT2AMEN1 | |
| SCHEMBL5252795 | 0.78 | DHODH (0.51) | DHODHALDH1A1GAAKMT2AMAPT | |
| SCHEMBL1908379 | 0.78 | DHODH (0.56) | DHODHALDH1A1GAAKMT2AMAPT | |
| SCHEMBL1375014 | 0.78 | DHODH (0.56) | DHODHALDH1A1GAAKMT2AMAPT | |
| SCHEMBL9470451 | 0.78 | DHODH (0.51) | DHODHALDH1A1GAAKMT2AMAPT | |
| SCHEMBL9074261 | 0.77 | CYP1A2 (0.47) | DHODHALDH1A1GAAKMT2AMAPT | |
| SCHEMBL9469965 | 0.77 | DHODH (0.48) | DHODHALDH1A1GAAKMT2AMAPT | |
| SCHEMBL3633702 | 0.74 | DHODH (0.51) | DHODHALDH1A1GAAKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991018902-A1 | SUBSTITUTED 1-H-PYRROLO[2,3-b]PYRIDINE-3-CARBOXAMIDES | SCHERING CORPORATION (US) | 1991-12-12 | — | — | WO | disclosed |
| US-5023265-A | Antiinflammatory agent; inhibits both 5-lipoxygenase and cyclooxygenase; rheumatoid arthritis, bursitis, tendonitis, gout; side effect reduction | SCHERING CORPORATION (US) | 1991-06-11 | — | — | US | disclosed |