Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.49 |
| ▸ | HTR1A | P08908 | 6/20 | 0.49 |
| ▸ | HTR2A | P28223 | 5/20 | 0.49 |
| ▸ | HTR7 | P34969 | 5/20 | 0.49 |
| ▸ | HTR6 | P50406 | 5/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9471703 | 0.89 | DRD2 (0.63) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL9130018 | 0.83 | DRD2 (0.46) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL9134861 | 0.82 | DRD2 (0.48) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL9130343 | 0.81 | HTR1A (0.45) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL9132087 | 0.81 | HTR1A (0.46) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL9132047 | 0.78 | HTR1A (0.42) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL9132000 | 0.77 | DRD2 (0.41) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL9134839 | 0.77 | ADRA1D (0.42) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL9132222 | 0.76 | HTR1A (0.40) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL9130468 | 0.76 | HTR1A (0.40) | DRD2HTR1AHTR2AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5274097-A | A 1-N-heterocyclic alkylene-3-carbo or heterocyclic ring oxypyrrolidine derivative | BAYER AKTIENGESELLSCHAFT (DE) | 1993-12-28 | — | — | US | disclosed |
| US-5037841-A | For treating nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1991-08-06 | — | — | US | disclosed |