Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ITGB7 | P26010 | 5/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.42 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.42 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9474084 | 0.91 | MEN1 (0.42) | GPR132ITGA4MEN1KMT2AITGB7 | |
| SCHEMBL9473162 | 0.91 | MEN1 (0.42) | GPR132ITGA4MEN1KMT2AITGB7 | |
| SCHEMBL9473565 | 0.89 | SCN3A (0.41) | GPR132ITGA4MEN1KMT2AITGB7 | |
| SCHEMBL9857334 | 0.88 | SCN3A (0.41) | ITGA4MEN1KMT2AITGB1SCN3A | |
| SCHEMBL9857009 | 0.88 | SCN3A (0.41) | ITGA4MEN1KMT2AITGB1SCN3A | |
| SCHEMBL9474767 | 0.87 | ITGA4 (0.42) | POLBGPR132ITGA4MEN1KMT2A | |
| SCHEMBL9473895 | 0.86 | MEN1 (0.42) | GPR132ITGA4MEN1KMT2AITGB7 | |
| SCHEMBL9473912 | 0.86 | MEN1 (0.42) | GPR132ITGA4MEN1KMT2AITGB7 | |
| SCHEMBL9856770 | 0.86 | ITGA4 (0.44) | ITGA4ITGB7ITGB1TP53 | |
| SCHEMBL9856896 | 0.82 | FAAH (0.41) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5234917-A | Hypotensive agent, treatment of renal failure or glaucoma | SMITHKLINE BEECHAM CORPORATION | 1993-08-10 | — | — | US | disclosed |
| EP-0437103-A2 | Substituted 5-(alkyl)carboxamide imidazoles | SMITHKLINE BEECHAM CORPORATION (US) | 1991-07-17 | — | — | EP | disclosed |