Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 14/20 | 0.52 |
| ▸ | EPAS1 | Q99814 | 13/20 | 0.52 |
| ▸ | MAOB | P27338 | 3/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | COXFA4 | O00483 | 1/20 | 0.42 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14098883 | 0.83 | HIF1A (0.51) | HIF1AEPAS1COXFA4EP300 | |
| SCHEMBL13535471 | 0.83 | COXFA4 (0.58) | HIF1AEPAS1COXFA4EP300 | |
| SCHEMBL482036 | 0.83 | HIF1A (0.49) | HIF1AEPAS1COXFA4EP300 | |
| SCHEMBL12315463 | 0.83 | HIF1A (0.42) | HIF1AEPAS1 | |
| SCHEMBL12315598 | 0.80 | COXFA4 (0.52) | HIF1AEPAS1COXFA4EP300 | |
| SCHEMBL2009830 | 0.78 | HIF1A (0.52) | HIF1AEPAS1COXFA4 | |
| SCHEMBL27340571 | 0.72 | HIF1A (0.59) | HIF1AEPAS1EP300 | |
| SCHEMBL3228582 | 0.72 | APP (0.82) | MAOBMAOAAPP | |
| SCHEMBL14666102 | 0.71 | HIF1A (0.39) | HIF1AEPAS1COXFA4EP300 | |
| SCHEMBL8885308 | 0.70 | MAPT (0.61) | HIF1AEPAS1COXFA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5254578-A | Cardiovascular disorders | SANKYO COMPANY, LIMITED (JP) | 1993-10-19 | — | — | US | disclosed |
| EP-0482931-A1 | Benzopyran derivatives having anti-hypertensive and vasodilatory activity, their preparation and their therapeutic use | Sankyo Company Limited (JP) | 1992-04-29 | — | — | EP | disclosed |