Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESPL1 | Q14674 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084973 | 0.87 | EPHX2 (0.35) | — | |
| SCHEMBL8077124 | 0.82 | PSEN1 (0.36) | ALDH1A1 | |
| SCHEMBL4259456 | 0.82 | BRD4 (0.47) | ALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL5578429 | 0.81 | CNR2 (0.35) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8077246 | 0.81 | HSD11B1 (0.34) | ALDH1A1 | |
| SCHEMBL9141298 | 0.81 | ABCC9 (0.36) | — | |
| SCHEMBL4260102 | 0.81 | ATM (0.45) | LMNAHTTSMN1; SMN2 | |
| SCHEMBL8084219 | 0.79 | KDM4E (0.36) | ALDH1A1CYP3A4CYP2C9CYP2C19HTT | |
| SCHEMBL8084230 | 0.78 | HRH4 (0.30) | — | |
| SCHEMBL8085076 | 0.78 | NPSR1 (0.34) | HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5254578-A | Cardiovascular disorders | SANKYO COMPANY, LIMITED (JP) | 1993-10-19 | — | — | US | disclosed |
| EP-0482931-A1 | Benzopyran derivatives having anti-hypertensive and vasodilatory activity, their preparation and their therapeutic use | Sankyo Company Limited (JP) | 1992-04-29 | — | — | EP | disclosed |