Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.31 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.31 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.31 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.31 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9476674 | 0.86 | ABCC9 (0.32) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL9475319 | 0.85 | ABCC9 (0.31) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL9476803 | 0.82 | ABCC9 (0.32) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL8027470 | 0.82 | — | — | |
| SCHEMBL9476372 | 0.82 | L3MBTL1 (0.36) | CHRM1ALDH1A1LMNACHRM2HTR1A | |
| SCHEMBL9475710 | 0.82 | ABCC9 (0.41) | CHRM1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL9475265 | 0.82 | ABCC9 (0.50) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL9478300 | 0.82 | ABCC9 (0.38) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL9476029 | 0.81 | ABCC9 (0.32) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL9475663 | 0.81 | ALOX5 (0.34) | ABCC9ABCC8KCNJ11KCNJ8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0477789-A1 | 1,3-Benzoxazine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1992-04-01 | — | — | EP | claimed |
| US-5270308-A | Hypotensives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-12-14 | — | — | US | disclosed |
| CN-1060467-A | 1,3-benzoxazine derivatives, its production method and purposes | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1992-04-22 | — | — | CN | disclosed |
| EP-0477789-A1 | 1,3-Benzoxazine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1992-04-01 | — | — | EP | disclosed |