Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.41 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.36 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9476282 | 0.92 | SMN1; SMN2 (0.41) | ALDH1A1KMT2AMEN1CACNA1FCACNA1D | |
| SCHEMBL9477103 | 0.84 | DCTPP1 (0.42) | ALDH1A1KMT2AMEN1CACNA1FCACNA1D | |
| SCHEMBL7406497 | 0.81 | CACNA1F (0.50) | ALDH1A1KMT2AMEN1CACNA1FCACNA1D | |
| SCHEMBL9476003 | 0.80 | CACNA1C (0.40) | ALDH1A1CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL9475146 | 0.77 | PTGDR2 (0.42) | ALDH1A1MAPT | |
| SCHEMBL9476368 | 0.76 | TP53 (0.40) | ALDH1A1KMT2AMEN1MAPTPOLB | |
| SCHEMBL9476024 | 0.73 | ALDH1A1 (0.41) | ALDH1A1KMT2AMEN1CACNA1FCACNA1D | |
| SCHEMBL7272032 | 0.73 | ALDH1A1 (0.48) | ALDH1A1KMT2AMEN1CACNA1FCACNA1D | |
| SCHEMBL9475454 | 0.71 | CACNA1D (0.53) | ALDH1A1KMT2AMEN1CACNA1FCACNA1D | |
| SCHEMBL9476027 | 0.71 | TP53 (0.40) | ALDH1A1MAPTPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5202330-A | Hypotensive and cardiovascular agent, reduces blood pressure in mammals | E. R. SQUIBB & SONS, INC. (US) | 1993-04-13 | — | — | US | disclosed |
| EP-0204317-A2 | 2-Thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxylic acid diesters and 3-acyl-5-pyrimidinecarboxylic acids and esters | E.R. Squibb & Sons, Inc. (US) | 1986-12-10 | — | — | EP | disclosed |