Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL944763 | 0.87 | TRPV1 (0.50) | BRD3TP53MAPTTRPV1MAPKAPK2 | |
| SCHEMBL949317 | 0.82 | BRD3 (0.40) | BRD3ABCB1ABCG2TP53MAPT | |
| SCHEMBL949319 | 0.82 | BRD3 (0.40) | BRD3ABCB1ABCG2TP53MAPT | |
| SCHEMBL950202 | 0.80 | S1PR1 (0.60) | — | |
| SCHEMBL947597 | 0.78 | S1PR1 (0.55) | TRPV1 | |
| SCHEMBL31293264 | 0.77 | SIRT1 (0.48) | BRD3TP53MAPTSIRT1L3MBTL1 | |
| SCHEMBL2567756 | 0.76 | S1PR1 (0.52) | SLC6A4MAPKAPK2ARKMT2A | |
| SCHEMBL948110 | 0.76 | S1PR1 (0.59) | — | |
| SCHEMBL946662 | 0.75 | S1PR1 (0.58) | TRPV1 | |
| SCHEMBL947568 | 0.75 | TRPV1 (0.49) | TP53MAPTTRPV1MAPKAPK2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011005295-A1 | MODULATORS OF THE SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |