Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 2/20 | 0.71 |
| ▸ | FEN1 | P39748 | 2/20 | 0.71 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.55 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9480386 | 0.86 | SLC9A1 (0.58) | ERCC5FEN1SLC9A1ALDH1A1HPGD | |
| SCHEMBL10747713 | 0.84 | ALDH1A1 (0.68) | ERCC5FEN1SLC9A1ALDH1A1HPGD | |
| SCHEMBL11805242 | 0.82 | ERCC5 (0.68) | ERCC5FEN1SLC9A1ALDH1A1HPGD | |
| SCHEMBL7118702 | 0.82 | ALDH1A1 (0.69) | ERCC5FEN1SLC9A1ALDH1A1HPGD | |
| SCHEMBL8337079 | 0.81 | KDM4E (0.60) | ERCC5FEN1SLC9A1ALDH1A1HPGD | |
| SCHEMBL1286218 | 0.80 | ALDH1A1 (0.70) | ERCC5FEN1SLC9A1ALDH1A1HPGD | |
| SCHEMBL10750999 | 0.79 | ALDH1A1 (0.65) | ERCC5FEN1SLC9A1ALDH1A1HPGD | |
| SCHEMBL9476258 | 0.79 | ERCC5 (0.63) | ERCC5FEN1SLC9A1ALDH1A1HPGD | |
| SCHEMBL9734801 | 0.78 | ERCC5 (0.67) | ERCC5FEN1SLC9A1ALDH1A1HPGD | |
| SCHEMBL11826852 | 0.78 | ALDH1A1 (0.63) | ERCC5FEN1SLC9A1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5214042-A | Use of 5-phenyl-2-furan esters, amides and ketones as neuroprotective agents | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1993-05-25 | — | — | US | disclosed |
| US-5118708-A | USE OF 5-PHENYL-2-FURAN ESTERS, AMIDES AND KETONES AS NEUROPROTECTIVE AGENTS | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1992-06-02 | — | — | US | disclosed |
| US-5091426-A | 5-PHENYL-2-FURAN KETONES AND USE AS ANTIEPILEPTIC AGENTS | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0404232-A1 | The use of 5-phenyl-2-furan ketones as antiepileptic agents | Norwich Eaton Pharmaceuticals, Inc. (US) | 1990-12-27 | — | — | EP | disclosed |
| EP-0404233-A2 | Novel use of 5-phenyl-2-furan esters, amides and ketones as neuroprotective agents | Norwich Eaton Pharmaceuticals, Inc. (US) | 1990-12-27 | — | — | EP | disclosed |