Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 3/20 | 0.43 |
| ▸ | CHRM1 known ✓ | P11229 | 3/20 | 0.43 |
| ▸ | CHRM3 known ✓ | P20309 | 3/20 | 0.43 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.40 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9663672 | 0.85 | MEN1 (0.51) | TDP1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL16353101 | 0.83 | TDP1 (0.50) | TDP1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL16353097 | 0.82 | ALDH1A1 (0.54) | TDP1CHRM2CHRM4CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL7209575 | 0.81 | MEN1 (0.61) | TDP1CHRM2CHRM1CHRM3MEN1 | |
| Hydrochloric Acid SCHEMBL17024386 | 0.81 | MEN1 (0.61) | TDP1CHRM2CHRM1CHRM3MEN1 | |
| SCHEMBL9481799 | 0.80 | MAPK1 (0.41) | MAPTMEN1KMT2ASMN1; SMN2MAPK1 | |
| SCHEMBL17033274 | 0.79 | DNM1 (0.60) | TDP1CHRM2CHRM1CHRM3MEN1 | |
| SCHEMBL4956181 | 0.79 | TDP1 (0.64) | TDP1TP53SMN1; SMN2MAPK1TSHR | |
| SCHEMBL9925312 | 0.77 | MEN1 (0.47) | TDP1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL16353094 | 0.77 | ALDH1A1 (0.53) | TDP1CHRM2CHRM4CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5194472-A | Low fusion temperature, improved polyester compatibility; toners for copiers | EASTMAN KODAK COMPANY (US) | 1993-03-16 | — | — | US | disclosed |
| US-5110977-A | Improved compatibility with polyester binder | EASTMAN KODAK COMPANY (US) | 1992-05-05 | — | — | US | disclosed |
| EP-0442105-A1 | Electrostatographic toner particles containing monomeric ester-containing quaternary ammonium salt charge agents | EASTMAN KODAK COMPANY (US) | 1991-08-21 | — | — | EP | disclosed |