Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 12/20 | 0.80 |
| ▸ | DRD2 | P14416 | 12/20 | 0.80 |
| ▸ | HTR2A | P28223 | 10/20 | 0.80 |
| ▸ | HTR7 | P34969 | 10/20 | 0.80 |
| ▸ | HTR6 | P50406 | 10/20 | 0.80 |
| ▸ | DRD4 | P21917 | 3/20 | 0.80 |
| ▸ | DRD3 | P35462 | 3/20 | 0.80 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.80 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.80 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.80 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.80 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.80 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.80 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.80 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.80 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.80 |
| ▸ | DRD5 | P21918 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9400972 | 0.89 | DRD2 (0.80) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9480686 | 0.89 | DRD2 (0.80) | HTR1ADRD2HTR2AHTR7HTR6 | |
| Ipsapirone SCHEMBL79574 | 0.89 | DRD2 (1.00) | HTR1ADRD2HTR2AHTR7HTR6 | |
| Ipsapirone SCHEMBL29356316 | 0.89 | DRD2 (1.00) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9400978 | 0.88 | DRD2 (0.78) | HTR1ADRD2HTR2AHTR7HTR6 | |
| Ipsapirone SCHEMBL121856 | 0.88 | DRD2 (0.98) | HTR1ADRD2HTR2AHTR7HTR6 | |
| Revospirone SCHEMBL1932725 | 0.87 | HTR1A (1.00) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9480100 | 0.87 | DRD2 (0.76) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9480709 | 0.86 | HTR1A (0.78) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9400959 | 0.85 | HTR1A (0.76) | HTR1ADRD2HTR2AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100009983-A1 | 5 HT RECEPTOR MEDIATED NEUROGENESIS | BRAINCELLS, INC. (US) | 2010-01-14 | — | — | US | disclosed |
| US-20100009983-A1 | 5 HT RECEPTOR MEDIATED NEUROGENESIS | BRAINCELLS, INC. (US) | 2010-01-14 | — | — | US | disclosed |
| US-5187276-A | Anxiolytics, neuroleptics, antidepressants, and nootropic agents | TROPONWERKE GMBH & CO. KG. (DE) | 1993-02-16 | — | — | US | disclosed |
| US-4988809-A | CENTRAL NERVOUS SYSTEM | TROPONWERKE GMBH & CO., KG (DE) | 1991-01-29 | — | — | US | disclosed |
| US-4937343-A | NEUROLEPTICS OR ANTIDEPRESSANTS | TROPONWERKE GMBH & CO. KG (DE) | 1990-06-26 | — | — | US | disclosed |
| US-4818756-A | CENTRAL NERVOUS SYSTEM DISORDERS | TROPONWERKE GMBH & CO., KG (DE) | 1989-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009983-A1 | 5 HT RECEPTOR MEDIATED NEUROGENESIS | HTR6, GAP43, HTR5A | HTR1A 7/4885DRD2 242/4885HTR2A 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.