Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29915678 | 0.98 | ACHE (0.39) | DRD2DRD1DRD4DRD5ACHE | |
| SCHEMBL110491 | 0.98 | ACHE (0.39) | DRD2DRD1DRD4DRD5ACHE | |
| SCHEMBL1884804 | 0.92 | S1PR1 (0.41) | ACHEMAOAS1PR1 | |
| SCHEMBL29915622 | 0.88 | MEN1 (0.42) | DRD2DRD1DRD4DRD5ACHE | |
| SCHEMBL111871 | 0.88 | MEN1 (0.42) | DRD2DRD1DRD4DRD5ACHE | |
| SCHEMBL28673277 | 0.84 | MEN1 (0.44) | ACHEMEN1ALDH1A1KMT2A | |
| Bromide SCHEMBL9480957 | 0.83 | DRD2 (0.40) | DRD2DRD1DRD4DRD5ACHE | |
| SCHEMBL107921 | 0.81 | NOTUM (0.40) | DRD2DRD1DRD4DRD5ACHE | |
| SCHEMBL29803467 | 0.81 | NOTUM (0.40) | DRD2DRD1DRD4DRD5ACHE | |
| SCHEMBL14235439 | 0.80 | MEN1 (0.40) | DRD2DRD1DRD4DRD5MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1047592-C | Tinctorial composition of 5,6-dihydroxyindole and dyeing method of keratose fibre | OREAL (FR) | 1999-12-22 | — | — | CN | disclosed |
| US-5178637-A | Hair dyes | L'OREAL (FR) | 1993-01-12 | — | — | US | disclosed |