Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 3/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.52 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.51 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9481804 | 0.93 | MCHR1 (0.47) | DRD4SIGMAR1SLC6A12SLC6A13RAB9A | |
| SCHEMBL9482200 | 0.86 | DRD4 (0.38) | DRD4SIGMAR1SLC6A12SLC6A13L3MBTL1 | |
| SCHEMBL9483648 | 0.81 | DRD4 (0.52) | DRD4SLC6A12SLC6A13MAOBKMT2A | |
| SCHEMBL9482226 | 0.80 | SIGMAR1 (0.55) | DRD4SIGMAR1SLC6A12SLC6A13L3MBTL1 | |
| SCHEMBL9852247 | 0.80 | SIGMAR1 (0.59) | DRD4SIGMAR1SLC6A12SLC6A13L3MBTL1 | |
| SCHEMBL9727135 | 0.80 | DRD4 (0.67) | DRD4SIGMAR1SLC6A12SLC6A13L3MBTL1 | |
| Dimethylamine SCHEMBL9852061 | 0.79 | DRD4 (0.63) | DRD4SIGMAR1SLC6A12SLC6A13POLB | |
| SCHEMBL9727088 | 0.76 | DRD4 (0.62) | DRD4SIGMAR1SLC6A12MAOBMCHR1 | |
| SCHEMBL9727190 | 0.76 | DRD4 (0.62) | DRD4SIGMAR1MAOBMCHR1 | |
| SCHEMBL9727173 | 0.73 | SIGMAR1 (0.57) | DRD4SIGMAR1SLC6A12SLC6A13MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5210090-A | Antiarrythmia | G. D. SEARLE & CO. (US) | 1993-05-11 | — | — | US | claimed |
| EP-0416581-A1 | Substituted N-benzylpiperidine amides | G.D. Searle & Co. (US) | 1991-03-13 | — | — | EP | claimed |
| US-5210090-A | Antiarrythmia | G. D. SEARLE & CO. (US) | 1993-05-11 | — | — | US | disclosed |
| EP-0416581-A1 | Substituted N-benzylpiperidine amides | G.D. Searle & Co. (US) | 1991-03-13 | — | — | EP | disclosed |