Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 5/20 | 0.67 |
| ▸ | MAOB | P27338 | 2/20 | 0.62 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.60 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.59 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.57 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylamine SCHEMBL9852061 | 0.97 | DRD4 (0.63) | DRD4MAOBSLC6A12SLC6A13SIGMAR1 | |
| SCHEMBL9727173 | 0.92 | SIGMAR1 (0.57) | DRD4MAOBSLC6A12SLC6A13SIGMAR1 | |
| SCHEMBL9727123 | 0.92 | DRD4 (0.69) | DRD4MAOBSLC6A12SLC6A13SIGMAR1 | |
| SCHEMBL9727095 | 0.90 | DRD4 (0.72) | DRD4MAOBSIGMAR1MCHR1 | |
| SCHEMBL9727255 | 0.88 | DRD4 (0.66) | DRD4MAOBSIGMAR1TMEM97 | |
| SCHEMBL9852073 | 0.88 | DRD4 (0.54) | DRD4MAOBSIGMAR1MCHR1 | |
| SCHEMBL9852082 | 0.86 | DRD4 (0.73) | DRD4MAOBSIGMAR1MCHR1 | |
| SCHEMBL9483648 | 0.86 | DRD4 (0.52) | DRD4MAOBSLC6A12SLC6A13MCHR1 | |
| SCHEMBL9727149 | 0.85 | DRD4 (0.58) | DRD4MAOBSIGMAR1MCHR1 | |
| SCHEMBL9852142 | 0.82 | CCR1 (0.54) | DRD4MAOBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098915-A | Antiarrhythmia agents | G. D. SEARLE & CO. (US) | 1992-03-24 | — | — | US | claimed |
| EP-0416581-A1 | Substituted N-benzylpiperidine amides | G.D. Searle & Co. (US) | 1991-03-13 | — | — | EP | claimed |