Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | RARB | P10826 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9484913 | 0.84 | L3MBTL1 (0.45) | L3MBTL1HCAR3TLR8CNR2PLA2G4A | |
| SCHEMBL10863993 | 0.82 | L3MBTL1 (0.45) | L3MBTL1HCAR3 | |
| SCHEMBL1224966 | 0.76 | TLR8 (0.41) | L3MBTL1TLR8CYP1A2CYP2C19GAA | |
| SCHEMBL10468639 | 0.75 | CNR2 (0.46) | HCAR3TLR8CNR2GAAMEN1 | |
| SCHEMBL28148357 | 0.75 | ALKBH1 (0.51) | — | |
| SCHEMBL7219828 | 0.74 | TP53 (0.46) | HCAR3TLR8CNR2CYP1A2CYP2C19 | |
| SCHEMBL30165248 | 0.73 | L3MBTL1 (0.44) | L3MBTL1HCAR3CYP1A2CYP2C19CYP2C9 | |
| SCHEMBL10401732 | 0.73 | L3MBTL1 (0.78) | L3MBTL1HCAR3PLA2G4AMEN1KMT2A | |
| SCHEMBL22748650 | 0.71 | PLA2G2A (0.43) | HCAR3CNR2CYP1A2CYP2C19GAA | |
| SCHEMBL27795662 | 0.70 | HCAR3 (0.43) | HCAR3TLR8CNR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5202330-A | Hypotensive and cardiovascular agent, reduces blood pressure in mammals | E. R. SQUIBB & SONS, INC. (US) | 1993-04-13 | — | — | US | disclosed |
| EP-0204317-A2 | 2-Thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxylic acid diesters and 3-acyl-5-pyrimidinecarboxylic acids and esters | E.R. Squibb & Sons, Inc. (US) | 1986-12-10 | — | — | EP | disclosed |