Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PTPRB | P23467 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9485102 | 0.84 | HCRTR1 (0.44) | NPSR1ALDH1A1GFERSMN1; SMN2MAPT | |
| SCHEMBL9448768 | 0.81 | TRPM8 (0.54) | NPSR1ALDH1A1MAPTTDP1NQO2 | |
| SCHEMBL9485336 | 0.80 | SMN1; SMN2 (0.45) | NTRK1ALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL14987242 | 0.77 | NQO2 (0.46) | MAPTNQO2GLAKMT2APOLB | |
| SCHEMBL6208424 | 0.74 | NTRK1 (0.46) | NTRK1ALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL9701422 | 0.73 | NTRK1 (0.37) | NTRK1ALDH1A1SMN1; SMN2MAPTPTPRB | |
| SCHEMBL31609244 | 0.71 | CA2 (0.47) | NPSR1ALDH1A1GFERMAPTTDP1 | |
| SCHEMBL4495406 | 0.71 | CYP4F2 (0.56) | SMN1; SMN2MAPTTDP1GLAKMT2A | |
| SCHEMBL9485040 | 0.71 | SMN1; SMN2 (0.41) | NTRK1ALDH1A1GFERSMN1; SMN2MAPT | |
| SCHEMBL8786889 | 0.71 | MAPT (0.51) | NPSR1SMN1; SMN2MAPTTDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5208248-A | Hydroxytryptamine Receptor Agonists | MERCK SHARPE & DOHME, LTD. (GB) | 1993-05-04 | — | — | US | disclosed |
| EP-0494774-A1 | Indazole-substituted fivemembered heteroaromatic compounds | MERCK SHARP & DOHME LTD. (GB) | 1992-07-15 | — | — | EP | disclosed |