Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9484567 | 0.84 | NTRK1 (0.41) | MAPTNPSR1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL8806905 | 0.80 | TRPM8 (0.53) | KDM4EALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL9485199 | 0.79 | HCRTR1 (0.50) | HCRTR1KDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL9485928 | 0.79 | HCRTR1 (0.52) | HCRTR1KDM4EMAPTALDH1A1MEN1 | |
| Oxalic Acid SCHEMBL9484406 | 0.76 | HCRTR1 (0.49) | HCRTR1KDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL8185257 | 0.76 | GNRHR (0.49) | HCRTR1KDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL2313218 | 0.75 | MAPT (0.54) | KDM4EMAPTNPSR1ALDH1A1MEN1 | |
| SCHEMBL8682336 | 0.74 | PTGIR (0.46) | HCRTR1KDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL3015738 | 0.74 | CYP4F2 (0.57) | MAPTALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL8682283 | 0.73 | KDM4E (0.40) | HCRTR1KDM4EMAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5208248-A | Hydroxytryptamine Receptor Agonists | MERCK SHARPE & DOHME, LTD. (GB) | 1993-05-04 | — | — | US | disclosed |
| EP-0494774-A1 | Indazole-substituted fivemembered heteroaromatic compounds | MERCK SHARP & DOHME LTD. (GB) | 1992-07-15 | — | — | EP | disclosed |