Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | PTPRB | P23467 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6208424 | 0.77 | NTRK1 (0.46) | NTRK1SMN1; SMN2ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL9485336 | 0.74 | SMN1; SMN2 (0.45) | NTRK1SMN1; SMN2ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL9484567 | 0.73 | NTRK1 (0.41) | NTRK1SMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL8786789 | 0.69 | THRA (0.44) | ALDH1A1KDM4ENFKB1LMNAMAPT | |
| SCHEMBL17871714 | 0.67 | PKM (0.49) | SMN1; SMN2ALDH1A1PKMLMNAMAPT | |
| SCHEMBL16771391 | 0.67 | MTNR1A (0.39) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| SCHEMBL28272283 | 0.65 | ROCK2 (0.35) | NTRK1SMN1; SMN2ALDH1A1KDM4ERAB9A | |
| SCHEMBL19665114 | 0.65 | MAPT (0.46) | ALDH1A1KDM4EPKMRAB9ANPC1 | |
| SCHEMBL8786042 | 0.64 | HTR1A (0.64) | SMN1; SMN2PKMNFKB1MAPTTSHR | |
| SCHEMBL20719731 | 0.64 | SMN1; SMN2 (0.39) | SMN1; SMN2L3MBTL1PKMRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0494774-A1 | Indazole-substituted fivemembered heteroaromatic compounds | MERCK SHARP & DOHME LTD. (GB) | 1992-07-15 | — | — | EP | disclosed |