Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | PPARA | Q07869 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 2/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9486139 | 0.99 | PPARG (0.52) | PPARGPPARAHTR7SIGMAR1DRD2 | |
| SCHEMBL4587500 | 0.92 | HTR7 (0.52) | PPARGPPARAHTR7SIGMAR1DRD2 | |
| SCHEMBL4587566 | 0.91 | PPARG (0.51) | PPARGPPARAHTR7SIGMAR1DRD2 | |
| Paliroden SCHEMBL29375649 | 0.91 | HTR7 (0.53) | PPARGPPARAHTR7SIGMAR1DRD2 | |
| Paliroden SCHEMBL4587135 | 0.91 | HTR7 (0.53) | PPARGPPARAHTR7SIGMAR1DRD2 | |
| Hydrochloric Acid SCHEMBL7393191 | 0.91 | MAOB (0.53) | PPARGPPARAHTR7SIGMAR1DRD2 | |
| SCHEMBL9501239 | 0.91 | SIGMAR1 (0.55) | PPARGPPARAHTR7SIGMAR1DRD2 | |
| SCHEMBL4587606 | 0.90 | PPARG (0.53) | PPARGPPARAHTR7SIGMAR1DRD2 | |
| SCHEMBL7820335 | 0.90 | PPARG (0.51) | PPARGPPARAHTR7SIGMAR1DRD2 | |
| Hydrochloric Acid SCHEMBL7394628 | 0.90 | PPARG (0.51) | PPARGPPARAHTR7SIGMAR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5266573-A | Constipation | ELF SANOFI (FR) | 1993-11-30 | — | — | US | claimed |
| EP-0412901-B1 | USE OF TRIFLUOROMETHYL-PHENYLTETRAHYDROPYRIDINES FOR THE MANUFACTURE OF MEDICAMENTS FOR THE TREATMENT OF INTESTINAL MOTILITY | ELF SANOFI (FR) | 1993-05-05 | — | — | EP | claimed |
| EP-0412901-A2 | Use of trifluoromethyl-phenyltetrahydropyridines for the manufacture of medicaments for the treatment of intestinal motility | ELF SANOFI (FR) | 1991-02-13 | — | — | EP | claimed |
| US-5266573-A | Constipation | ELF SANOFI (FR) | 1993-11-30 | — | — | US | disclosed |
| EP-0412901-B1 | USE OF TRIFLUOROMETHYL-PHENYLTETRAHYDROPYRIDINES FOR THE MANUFACTURE OF MEDICAMENTS FOR THE TREATMENT OF INTESTINAL MOTILITY | ELF SANOFI (FR) | 1993-05-05 | — | — | EP | disclosed |
| US-5109005-A | TRIFLUOROMETHYLPHENYLTETRAHYDROPYRIDINES FOR THE TREATMENT AND/OR PROPHYLAXIS OF INTESTINAL MOTILITY DISORDERS | SANOFI (FR) | 1992-04-28 | — | — | US | disclosed |
| EP-0412901-A2 | Use of trifluoromethyl-phenyltetrahydropyridines for the manufacture of medicaments for the treatment of intestinal motility | ELF SANOFI (FR) | 1991-02-13 | — | — | EP | disclosed |
| EP-0412901-A2 | Use of trifluoromethyl-phenyltetrahydropyridines for the manufacture of medicaments for the treatment of intestinal motility | ELF SANOFI (FR) | 1991-02-13 | — | — | EP | disclosed |