Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.55 |
| ▸ | HTR7 | P34969 | 2/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.52 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9485989 | 0.99 | SIGMAR1 (0.54) | SIGMAR1HTR7PPARGPPARAKCNA3 | |
| SCHEMBL4589037 | 0.96 | HTR7 (0.52) | SIGMAR1HTR7PPARGPPARAKCNA3 | |
| Paliroden SCHEMBL29375649 | 0.95 | HTR7 (0.53) | SIGMAR1HTR7PPARGPPARAKCNA3 | |
| Paliroden SCHEMBL4587135 | 0.95 | HTR7 (0.53) | SIGMAR1HTR7PPARGPPARAKCNA3 | |
| SCHEMBL4588554 | 0.94 | HTR7 (0.52) | SIGMAR1HTR7PPARGPPARAKCNA3 | |
| SCHEMBL4587500 | 0.92 | HTR7 (0.52) | SIGMAR1HTR7PPARGPPARAKCNA3 | |
| Hydrochloric Acid SCHEMBL7393191 | 0.91 | MAOB (0.53) | SIGMAR1HTR7PPARGPPARAKCNA3 | |
| SCHEMBL9485644 | 0.91 | PPARG (0.53) | SIGMAR1HTR7PPARGPPARAKCNA3 | |
| SCHEMBL4588837 | 0.90 | PPARG (0.56) | SIGMAR1HTR7PPARGPPARAKCNA3 | |
| Hydrochloric Acid SCHEMBL9486139 | 0.90 | PPARG (0.52) | SIGMAR1HTR7PPARGPPARAKCNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0412901-B1 | USE OF TRIFLUOROMETHYL-PHENYLTETRAHYDROPYRIDINES FOR THE MANUFACTURE OF MEDICAMENTS FOR THE TREATMENT OF INTESTINAL MOTILITY | ELF SANOFI (FR) | 1993-05-05 | — | — | EP | disclosed |
| EP-0412901-A2 | Use of trifluoromethyl-phenyltetrahydropyridines for the manufacture of medicaments for the treatment of intestinal motility | ELF SANOFI (FR) | 1991-02-13 | — | — | EP | disclosed |