Styrene

Styrene

SCHEMBL9488136

C=Cc1ccccc1.C=Cc1ccccc1C=C.ClCC=Cc1ccccc1

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.50
TSHR P16473 1/20 0.50
IDO1 P14902 2/20 0.39
PAM P19021 1/20 0.39
NPC1 O15118 1/20 0.38
POLB P06746 1/20 0.38
MAPT P10636 1/20 0.38
MAPK1 P28482 1/20 0.38
RECQL P46063 1/20 0.38
RAB9A P51151 1/20 0.38
PTGER4 P35408 1/20 0.37
PTGER3 P43115 1/20 0.37
PTGER2 P43116 1/20 0.37
HTR2A P28223 3/20 0.37
TRPA1 O75762 1/20 0.36
NFE2L2 Q16236 1/20 0.36
MAOB P27338 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL451576 0.96 ALDH1A1 (0.43) ALDH1A1TSHRIDO1PAMNPC1
Styrene SCHEMBL1507248 0.93 ALDH1A1 (0.58) ALDH1A1TSHRIDO1PAMNPC1
SCHEMBL15421494 0.88 HTR2A (0.38) ALDH1A1TSHRIDO1PAMPTGER4
SCHEMBL17313675 0.85 NR1I2 (0.43) TSHRPAMHTR2A
SCHEMBL308354 0.85 ALDH1A1 (0.38) ALDH1A1TSHRIDO1PAMRAB9A
SCHEMBL9044783 0.82 IDO1 (0.52) IDO1PAMNPC1RAB9AHTR2A
SCHEMBL15852 0.82 IDO1 (0.52) IDO1PAMNPC1RAB9AHTR2A
Benzene SCHEMBL1225975 0.82 IDO1 (0.52) IDO1PAMNPC1RAB9AHTR2A
Benzene SCHEMBL1225972 0.82 IDO1 (0.52) IDO1PAMNPC1RAB9AHTR2A
SCHEMBL39674 0.82 IDO1 (0.52) IDO1PAMNPC1RAB9AHTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0154343-B1 ADSORBENT Research Development Corporation of Japan (JP) 1991-06-19 EP claimed
EP-0322209-B1 COMPOUNDS SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1993-02-10 EP disclosed
EP-0154343-B1 ADSORBENT Research Development Corporation of Japan (JP) 1991-06-19 EP disclosed
US-4954339-A ANTICHOLESTEROL AGENTS, SEQUESTERING SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1990-09-04 US disclosed
WO-1989005828-A1 COMPOUNDS SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1989-06-29 WO disclosed
EP-0322209-A1 Compounds SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1989-06-28 EP disclosed
US-4785021-A OPTICAL RESOLUTION RESEARCH DEVELOPMENT CORP. OF JAPAN (JP) 1988-11-15 US disclosed
US-4747956-A CROSSLINKED POLYAMINO ACID RESEARCH DEVELOPMENT CORPORATION (JP) 1988-05-31 US disclosed
US-4694044-A Adsorbent RESEARCH DEVELOPMENT CORP. OF JAPAN (JP) 1987-09-15 US disclosed
EP-0154343-A2 Adsorbent Research Development Corporation of Japan (JP) 1985-09-11 EP disclosed
US-4294933-A SILANE-MODIFIED POLYOLEFIN RESIN MITSUBISHI PETROCHEMICAL COMPANY LIMITED (JP) 1981-10-13 US disclosed