SCHEMBL9489385

SCHEMBL9489385

O=CNOC(=O)CC(=O)O

nearest known ligand 0.38

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
LDHA P00338 1/20 0.38
SRR Q9GZT4 1/20 0.38
TSHR P16473 2/20 0.31
KDM4E B2RXH2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27532276 0.98 LDHA (0.36) LDHASRRTSHRKDM4E
Butane SCHEMBL8580310 0.91 FFAR3 (0.32) LDHASRRTSHR
SCHEMBL16431049 0.87 MGAM (0.33) TSHR
SCHEMBL26907179 0.81 EGLN1 (0.41) TSHRKDM4E
SCHEMBL28323922 0.78 MGAM (0.50) TSHRKDM4E
SCHEMBL28508762 0.76 TSHR (0.48) TSHR
SCHEMBL27967732 0.75
SCHEMBL27882032 0.75
SCHEMBL28314137 0.75
SCHEMBL28165411 0.75 TSHR (0.46) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1278245-A Malonic acid based matric metalloproteinase inhibitors ROCHE DIAGNOSTICS GMBH (DE) 2000-12-27 CN disclosed
CN-1238334-A Dialkyl tin compound of three-ligand binuclear diacyl hydroxamic acids and its synthesis UNIV SHANXI (CN) 1999-12-15 CN disclosed
CN-1238335-A Dialkyl tin compound of two-ligand binuclear diacyl hydroxamic acids and its synthesis UNIV SHANXI (CN) 1999-12-15 CN disclosed
CN-1238339-A Dialkyl tin compound of mononuclear diacyl hydroxamic acids and its synthesis UNIV SHANXI (CN) 1999-12-15 CN disclosed
EP-0315519-B1 AMINOPIMELIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINES ROUSSEL-UCLAF (FR) 1993-03-24 EP disclosed
EP-0284461-B1 DERIVATIVES OF GLUTAMIC ACID, THEIR SALTS, PROCESS FOR THEIR PREPARATION, USE AS MEDICINES AND COMPOSITIONS CONTAINING THEM ROUSSEL-UCLAF (FR) 1991-06-12 EP disclosed
EP-0315519-A2 Aminopimelic acid derivatives, process for their preparation and their use as medicines ROUSSEL-UCLAF (FR) 1989-05-10 EP disclosed
EP-0284461-A1 Derivatives of glutamic acid, their salts, process for their preparation, use as medicines and compositions containing them ROUSSEL-UCLAF (FR) 1988-09-28 EP disclosed