Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B10 | O60218 | 1/20 | 0.48 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.35 |
| ▸ | PGR | P06401 | 2/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NQO2 | P16083 | 2/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10677181 | 0.81 | IDO1 (0.53) | AKR1B10AKR1A1AKR1B1CYP1A2ALDH1A1 | |
| SCHEMBL16952213 | 0.80 | CA1 (0.42) | CYP1A2ALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL7089898 | 0.78 | AKR1B10 (0.47) | AKR1B10AKR1A1AKR1B1CYP1A2ALDH1A1 | |
| SCHEMBL9575279 | 0.78 | IMPDH2 (0.57) | AKR1B10AKR1A1AKR1B1ALDH1A1NR3C1 | |
| SCHEMBL7089895 | 0.78 | AKR1B10 (0.62) | AKR1B10AKR1A1AKR1B1HPGDMAPT | |
| SCHEMBL9007508 | 0.78 | AKR1B10 (0.47) | AKR1B10AKR1A1AKR1B1ALDH1A1HPGD | |
| SCHEMBL9491139 | 0.77 | AKR1B10 (0.40) | AKR1B10AKR1A1AKR1B1CYP1A2ALDH1A1 | |
| SCHEMBL12506928 | 0.77 | CYP1A2 (0.50) | CYP1A2CYP2A6ALDH1A1NR3C1PGR | |
| SCHEMBL5254383 | 0.77 | CYP1A2 (0.50) | CYP1A2CYP2A6ALDH1A1HPGDHSD17B10 | |
| SCHEMBL9575302 | 0.76 | AKR1B10 (0.61) | AKR1B10AKR1A1AKR1B1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4499310-A | 5-Methyl-1-(trifluoromethyl)-2-naphthalenol, process for its preparation and ethers thereof | AYERST, MCKENNA & HARRISON, INC. (CA) | 1985-02-12 | — | — | US | claimed |
| EP-0322256-B1 | N-ACYL-N-NAPHTHOYLGLYCINES AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-03-24 | — | — | EP | disclosed |
| EP-0322255-B1 | N-ACYL-N-NAPHTHOYLGLYCINES AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-03-24 | — | — | EP | disclosed |
| US-4962224-A | TREATMENT OR PREVENTION OF DIABETES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-10-09 | — | — | US | disclosed |
| WO-1989005793-A1 | N-ACYL-N-NAPHTHOYLGLYCINES AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-06-29 | — | — | WO | disclosed |
| EP-0322256-A1 | N-acyl-N-naphthoylglycines as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-06-28 | — | — | EP | disclosed |
| EP-0322255-A1 | N-acyl-N-naphthoylglycines as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-06-28 | — | — | EP | disclosed |
| US-4820727-A | TREATING DIABETIC COMPLICATIONS-VISION DEFECTS, KIDNEY AND NERVOUS SYSTEM DISORDERS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-04-11 | — | — | US | disclosed |
| US-4562286-A | Process for preparing methoxytrifluoromethylnaphthoic acid from dimethylnaphthalene | OCCIDENTAL CHEMICAL CORPORATION (US) | 1985-12-31 | — | — | US | disclosed |
| US-4560794-A | Process for preparing methoxytrifluoromethylnaphthoic acid from methylnaphthoic acid | OCCIDENTAL CHEMICAL CORPORATION (US) | 1985-12-24 | — | — | US | disclosed |
| US-4499310-A | 5-Methyl-1-(trifluoromethyl)-2-naphthalenol, process for its preparation and ethers thereof | AYERST, MCKENNA & HARRISON, INC. (CA) | 1985-02-12 | — | — | US | disclosed |
| US-4408077-A | 6-(Lower alkoxy)-5-(trifluoromethyl)-1-naphthalenecarboxaldehydes | AYERST, MCKEENA & HARRISON, INC. (CA) | 1983-10-04 | — | — | US | disclosed |