Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
| ▸ | EP300 | Q09472 | 1/20 | 0.51 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.51 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.47 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9489666 | 0.81 | AKR1B10 (0.48) | IDO1EP300KAT8AKR1B10AKR1A1 | |
| SCHEMBL9437116 | 0.80 | ALDH1A1 (0.54) | IDO1EP300KAT8ALDH1A1TDP1 | |
| SCHEMBL9488948 | 0.80 | IDO1 (0.41) | IDO1EP300KAT8AKR1B10AKR1A1 | |
| SCHEMBL10415791 | 0.77 | AKR1B10 (0.60) | AKR1B10AKR1A1AKR1B1MAPTKDM4E | |
| SCHEMBL11674477 | 0.77 | IDO1 (0.62) | IDO1EP300KAT8ALDH1A1TDP1 | |
| SCHEMBL7089895 | 0.76 | AKR1B10 (0.62) | AKR1B10AKR1A1AKR1B1HPGDMAPT | |
| SCHEMBL9575279 | 0.76 | IMPDH2 (0.57) | AKR1B10AKR1A1AKR1B1ALDH1A1MAPT | |
| SCHEMBL9007508 | 0.76 | AKR1B10 (0.47) | IDO1AKR1B10AKR1A1AKR1B1ALDH1A1 | |
| SCHEMBL7089898 | 0.76 | AKR1B10 (0.47) | AKR1B10AKR1A1AKR1B1ALDH1A1TDP1 | |
| SCHEMBL9575302 | 0.75 | AKR1B10 (0.61) | AKR1B10AKR1A1AKR1B1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4743611-A | TREATMENT OF DIABETIC COMPLICATIONS | AMERICAN HOME PRODUCTS CORP. (US) | 1988-05-10 | — | — | US | disclosed |
| EP-0251784-A2 | Naphthalenylsulfonylimidazolidinediones and their thioxo analogs | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-01-07 | — | — | EP | disclosed |