SCHEMBL9490452

SCHEMBL9490452

COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1C(C)c1c[nH]c2ccc(CCNC(=O)N3CCOCC3)cc12

nearest known ligand 0.45

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.41
RAB9A P51151 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9489489 0.93 TDP1 (0.43) KMT2ARAB9A
SCHEMBL9490939 0.91 KMT2A (0.40) KMT2ARAB9A
SCHEMBL9488829 0.86 MEN1 (0.40) KMT2A
SCHEMBL9488909 0.85 KMT2A (0.45) KMT2A
SCHEMBL9489892 0.85 KMT2A (0.45) KMT2A
SCHEMBL9372122 0.80
SCHEMBL9372406 0.80
SCHEMBL8532771 0.80
SCHEMBL8530545 0.80 ALKBH2 (0.43)
SCHEMBL9527977 0.79 CYSLTR1 (0.41) KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0337766-B1 HETERA-ALIPHATIC CARBOXAMIDES ICI AMERICAS INC. (US) 1993-03-10 EP disclosed
US-5041460-A Antiallergens, antiinflammatory agents and leukotriene antagonists ICI AMERICAS INC. (US) 1991-08-20 US disclosed
EP-0337766-A1 Hetera-aliphatic carboxamides ICI AMERICAS INC. (US) 1989-10-18 EP disclosed