SCHEMBL9492162

SCHEMBL9492162

N#CC(CN1CCCC1)c1ccc(Cl)c(Cl)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A3 Q01959 7/20 0.47
POLB P06746 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
HTR1A P08908 1/20 0.43
HTR7 P34969 1/20 0.43
OPRK1 P41145 2/20 0.43
SLC6A4 P31645 4/20 0.42
SLC6A2 P23975 4/20 0.42
SIGMAR1 Q99720 3/20 0.42
GRIN2D O15399 1/20 0.42
GRIN3B O60391 1/20 0.42
GRIN1 Q05586 1/20 0.42
GRIN2A Q12879 1/20 0.42
GRIN2B Q13224 1/20 0.42
GRIN2C Q14957 1/20 0.42
GRIN3A Q8TCU5 1/20 0.42
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
NPSR1 Q6W5P4 2/20 0.41
OPRM1 P35372 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9736135 0.84 SLC6A3 (0.51) SLC6A3POLBSMN1; SMN2SLC6A4SLC6A2
SCHEMBL26923436 0.76 POLB (0.47) SLC6A3POLBSMN1; SMN2HTR1AHTR7
SCHEMBL10990350 0.75 SLC6A3 (0.47) SLC6A3SMN1; SMN2SLC6A4SLC6A2MEN1
SCHEMBL8894427 0.74 ALDH1A1 (0.46) POLBSMN1; SMN2SIGMAR1MEN1KMT2A
SCHEMBL9491368 0.74 POLB (0.45) SLC6A3POLBSMN1; SMN2HTR1AHTR7
SCHEMBL30021683 0.74 SLC6A3 (0.46) SLC6A3SMN1; SMN2SLC6A4SLC6A2MEN1
SCHEMBL15758409 0.73 HTR1A (0.46) SLC6A3POLBSMN1; SMN2HTR1AHTR7
SCHEMBL28484711 0.73 HTR1A (0.46) SLC6A3POLBSMN1; SMN2HTR1AHTR7
Hydrochloric Acid SCHEMBL6207482 0.72 ACHE (0.56) SLC6A3SMN1; SMN2SLC6A4SLC6A2MEN1
SCHEMBL15836354 0.72 HTR1A (0.48) SLC6A3POLBSMN1; SMN2HTR1AHTR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0324791-B1 ARYL-N-AMINOALKYL-4-(SULFONAMIDO)BENZAMIDES, ANTIARRHYTMIC AGENTS AND COMPOSITIONS THEREOF SCHERING AKTIENGESELLSCHAFT (DE) 1993-03-24 EP disclosed
US-4920116-A ANTIARRHYTHMIA AGENTS SCHERING A.G. (DE) 1990-04-24 US disclosed
EP-0324791-A1 ARYL-N-AMINOALKYL-4-(SULFONAMIDO)BENZAMIDES, ANTIARRHYTMIC AGENTS AND COMPOSITIONS THEREOF. SCHERING AG (DE) 1989-07-26 EP disclosed
WO-1988002362-A1 ARYL-N-AMINOALKYL-4-(SULFONAMIDO)BENZAMIDES, ANTIARRHYTMIC AGENTS AND COMPOSITIONS THEREOF SCHERING AKTIENGESELLSCHAFT (DE) 1988-04-07 WO disclosed