Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | IL1B | P01584 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 8/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SRR | Q9GZT4 | 2/20 | 0.36 |
| ▸ | USP5 | P45974 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL949330 | 0.88 | IDH1 (0.39) | CASP1IL1BIDH1KDM4EMEN1 | |
| SCHEMBL2801277 | 0.87 | CASP1 (0.41) | CASP1IL1BIDH1TBXAS1KDM4E | |
| SCHEMBL27501506 | 0.84 | CASP1 (0.42) | CASP1IL1BIDH1TBXAS1KMT2A | |
| SCHEMBL949769 | 0.83 | CASP1 (0.33) | CASP1IL1BIDH1 | |
| SCHEMBL951482 | 0.78 | GABRP (0.34) | KDM4EMAPTHSD17B10ALOX5 | |
| SCHEMBL4496457 | 0.77 | KDM4E (0.52) | CASP1IL1BIDH1TBXAS1KDM4E | |
| SCHEMBL27473868 | 0.77 | GAA (0.40) | CASP1IL1BIDH1MEN1MAPT | |
| SCHEMBL950205 | 0.75 | ELANE (0.45) | KDM4EMAPTCYP2C9CYP2C19KMT2A | |
| SCHEMBL949978 | 0.75 | CASP1 (0.69) | CASP1IL1BKDM4EMEN1POLB | |
| SCHEMBL8402040 | 0.74 | KDM4E (0.38) | KDM4EMEN1POLBKMT2AUSP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110015371-A1 | Inhibitors of interleukin-1 beta converting enzyme | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015371-A1 | Inhibitors of interleukin-1 beta converting enzyme | IL1B, IL1A, IL1R1 | CASP1 5/4885IL1B 1/4885IDH1 1052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.