Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 2/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 2/20 | 0.33 |
| ▸ | EDNRB | P24530 | 2/20 | 0.32 |
| ▸ | EDNRA | P25101 | 2/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.32 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9497035 | 0.89 | AGTR1 (0.38) | AGTR1AGTR2 | |
| SCHEMBL9499263 | 0.84 | AGTR1 (0.37) | AGTR1AGTR2 | |
| SCHEMBL9496620 | 0.84 | AGTR1 (0.36) | AGTR1AGTR2 | |
| SCHEMBL9454425 | 0.81 | AGTR1 (0.47) | AGTR1AGTR2 | |
| SCHEMBL9494917 | 0.81 | AGTR1 (0.37) | AGTR1AGTR2EDNRBEDNRAPOLB | |
| SCHEMBL9494062 | 0.81 | AGTR1 (0.66) | AGTR1AGTR2 | |
| SCHEMBL9455081 | 0.75 | AGTR1 (0.41) | AGTR1AGTR2 | |
| SCHEMBL9454842 | 0.75 | AGTR1 (0.43) | AGTR1AGTR2 | |
| SCHEMBL9455048 | 0.75 | AGTR1 (0.42) | AGTR1AGTR2 | |
| SCHEMBL9454891 | 0.75 | AGTR1 (0.42) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5236937-A | Treating hypertension, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |