Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 4/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NISCH | Q9Y2I1 | 8/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14042330 | 0.99 | SLC6A2 (0.46) | WDR5SLC6A2SLC6A4NPSR1L3MBTL1 | |
| SCHEMBL4114349 | 0.92 | WDR5 (0.48) | WDR5SLC6A2SLC6A4NPSR1L3MBTL1 | |
| Iodide SCHEMBL951481 | 0.88 | KDM4E (0.51) | NPSR1L3MBTL1KDM4EHTTNISCH | |
| SCHEMBL949042 | 0.86 | KDM4E (0.52) | NPSR1L3MBTL1KDM4EHTTNISCH | |
| SCHEMBL4788615 | 0.85 | PTGIR (0.44) | SLC6A2SLC6A4NPSR1L3MBTL1KDM4E | |
| SCHEMBL4785397 | 0.85 | PTGIR (0.47) | WDR5NPSR1L3MBTL1KDM4EHTT | |
| SCHEMBL4106896 | 0.85 | WDR5 (0.48) | WDR5SLC6A2SLC6A4NPSR1NISCH | |
| SCHEMBL4786568 | 0.85 | HTR1B (0.49) | WDR5SLC6A2SLC6A4NPSR1L3MBTL1 | |
| SCHEMBL4788583 | 0.85 | NISCH (0.43) | NPSR1L3MBTL1KDM4EHTTNISCH | |
| SCHEMBL3431450 | 0.82 | WDR5 (0.46) | WDR5NPSR1KDM4ENISCHCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7871960-B2 | 1-(Imidazolin-2-yl)amino-1,2-diphenylethane compounds for combating animal pests | BASF SE (DE) | 2011-01-18 | — | — | US | disclosed |
| EP-1888533-B1 | 1-(IMIDAZOLIN-2-YL)AMINO-1,2-DIPHENYLETHANE COMPOUNDS FOR COMBATING ANIMAL PESTS | BASF SE (DE) | 2010-12-15 | — | — | EP | disclosed |
| US-20080200335-A1 | 1-(Imidazolin-2-Yl)Amino-1,2-Diphenylethane Compounds For Combating Animal Pests | BASF AKTIENGESELLSCHAFT (DE) | 2008-08-21 | — | — | US | disclosed |
| EP-1888533-A1 | 1-(IMIDAZOLIN-2-YL)AMINO-1,2-DIPHENYLETHANE COMPOUNDS FOR COMBATING ANIMAL PESTS | BASF AKTIENGESELLSCHAFT (DE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006125748-A1 | 1-(IMIDAZOLIN-2-YL)AMINO-1,2-DIPHENYLETHANE COMPOUNDS FOR COMBATING ANIMAL PESTS | BASF AKTIENGESELLSCHAFT (DE) | 2006-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200335-A1 | 1-(Imidazolin-2-Yl)Amino-1,2-Diphenylethane Compounds For Combating Animal Pests | ANXA1, ANXA11, AGO2 | WDR5 2593/4885SLC6A2 2618/4885SLC6A4 4090/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.