Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3602309 | 0.77 | ACHE (0.46) | ACHECYP19A1KDM4EMAPT | |
| SCHEMBL9495652 | 0.73 | MEN1 (0.45) | ACHEMAPTHTTNPC1RAB9A | |
| SCHEMBL14939214 | 0.73 | ACHE (0.62) | ACHECYP19A1KDM4ELMNAPOLB | |
| SCHEMBL27532854 | 0.71 | ALDH1A1 (0.52) | ACHECYP19A1KDM4EMAPTDRD2 | |
| SCHEMBL15746282 | 0.71 | ACHE (1.00) | ACHECYP19A1KDM4ELMNAPOLB | |
| SCHEMBL31297867 | 0.71 | ACHE (0.70) | ACHECYP19A1KDM4ELMNAPOLB | |
| SCHEMBL11204280 | 0.70 | HTT (0.51) | LMNAPOLBMAPTHTT | |
| SCHEMBL25604493 | 0.70 | ACHE (0.68) | ACHECYP19A1CA1CA2KDM4E | |
| SCHEMBL30070593 | 0.70 | PSEN1 (0.33) | ACHECA1CA2 | |
| SCHEMBL28529968 | 0.70 | ACHE (0.62) | ACHECYP19A1CA1CA2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0522000-A1 | 5-LIPOXYGENASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-01-13 | — | — | EP | disclosed |
| WO-1991014674-A2 | 5-LIPOXYGENASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1991-10-03 | — | — | WO | disclosed |