Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | METAP1 | P53582 | 4/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9495652 | 0.86 | MEN1 (0.45) | ACHEMETAP1MAPT | |
| SCHEMBL31185489 | 0.84 | IDO1 (0.42) | ACHECYP19A1METAP1SIGMAR1KDM4E | |
| SCHEMBL27532854 | 0.84 | ALDH1A1 (0.52) | ACHECYP19A1SIGMAR1PSEN1PSEN2 | |
| SCHEMBL27675006 | 0.82 | MAOB (0.43) | ACHECYP19A1METAP1SIGMAR1TDP1 | |
| SCHEMBL15670682 | 0.80 | ACHE (0.53) | ACHECYP19A1METAP1MAPTTSHR | |
| SCHEMBL9740101 | 0.77 | ACHE (0.50) | ACHECYP19A1METAP1KDM4EALDH1A1 | |
| SCHEMBL9495668 | 0.77 | ACHE (0.55) | ACHECYP19A1KDM4EMAPT | |
| SCHEMBL11289312 | 0.75 | ACHE (0.44) | ACHECYP19A1METAP1KDM4EALDH1A1 | |
| SCHEMBL10650245 | 0.75 | CYSLTR1 (0.43) | ACHEALDH1A1MAPT | |
| SCHEMBL3870840 | 0.75 | ACHE (0.50) | ACHECYP19A1METAP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8541475-B2 | MAO-B inhibitors useful for treating obesity | JENRIN DISCOVERY, INC. (US) | 2013-09-24 | — | — | US | disclosed |
| US-20100168068-A1 | MAO-B INHIBITORS USEFUL FOR TREATING OBESITY | JENRIN DISCOVERY (US) | 2010-07-01 | — | — | US | disclosed |
| US-7649115-B2 | MAO-B inhibitors useful for treating obesity | JENRIN DISCOVERY, INC. (US) | 2010-01-19 | — | — | US | disclosed |
| EP-1890690-A2 | MAO-B INHIBITORS USEFUL FOR TREATING ABESITY | Jenrin Discovery (US) | 2008-02-27 | — | — | EP | disclosed |
| US-20070088004-A1 | Monoamine oxidase-B inhibitors; , and/or cardiometabolic disorders ( hypertension, dyslipidemias, high blood pressure, and insulin resistance); | JENRIN DISCOVERY, INC. | 2007-04-19 | — | — | US | disclosed |
| WO-2006130707-A2 | MAO-B INHIBITORS USEFUL FOR TREATING OBESITY | JENRIN DISCOVERY (US) | 2006-12-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070088004-A1 | Monoamine oxidase-B inhibitors; , and/or cardiometabolic disorders ( hypertension, dyslipidemias, high blood pressure, and insulin resistance); | MAOB, MAOA, APOB | ACHE 526/4885CYP19A1 85/4885METAP1 433/4885 |
| US-20100168068-A1 | MAO-B INHIBITORS USEFUL FOR TREATING OBESITY | MAOB, MAOA, GPR119 | ACHE 717/4885CYP19A1 32/4885METAP1 500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.