Sugi Predict

Sugi Predict / Compounds / SCHEMBL949608

SCHEMBL949608

SCHEMBL949608

[CH](c1ccccc1)c1ccco1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 9/20 0.50
▸ HCAR2 Q8TDS4 1/20 0.45
▸ KMT2A Q03164 6/20 0.44
▸ MAPT P10636 9/20 0.42
▸ F2 P00734 2/20 0.42
▸ POLB P06746 4/20 0.42
▸ L3MBTL1 Q9Y468 4/20 0.42
▸ HTT P42858 1/20 0.42
▸ MEN1 O00255 5/20 0.42
▸ MAPK1 P28482 3/20 0.42
▸ RECQL P46063 2/20 0.42
▸ NPSR1 Q6W5P4 2/20 0.42
▸ GAA P10253 2/20 0.42
▸ G6PC1 P35575 1/20 0.42
▸ MASP2 O00187 1/20 0.41
▸ KDM4E B2RXH2 3/20 0.40
▸ HSD17B10 Q99714 2/20 0.40
▸ TSHR P16473 1/20 0.40
▸ CYP2C19 P33261 1/20 0.40
▸ PLA2G7 Q13093 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL490330 0.82 ALDH1A1 (0.62) ALDH1A1HCAR2KMT2AMAPTF2
SCHEMBL2155508 0.80 ALDH1A1 (0.45) ALDH1A1HCAR2KMT2AMAPTPOLB
SCHEMBL8893592 0.80 HSP90AA1 (0.56) ALDH1A1KMT2AMAPTPOLBL3MBTL1
SCHEMBL11643528 0.79 HCAR2 (0.53) ALDH1A1HCAR2KMT2AMAPTF2
SCHEMBL8807020 0.79 HCAR2 (0.53) ALDH1A1HCAR2KMT2AMAPTF2
Benzaldehyde SCHEMBL2519784 0.76 ALDH1A1 (0.75) ALDH1A1HCAR2KMT2AMAPTF2
SCHEMBL11319144 0.76 F2 (0.59) ALDH1A1HCAR2KMT2AMAPTF2
SCHEMBL11319146 0.76 F2 (0.59) ALDH1A1HCAR2KMT2AMAPTF2
SCHEMBL11184778 0.76 ALDH1A1 (0.46) ALDH1A1KMT2AMAPTPOLBL3MBTL1
SCHEMBL29289415 0.76 ALDH1A1 (0.41) ALDH1A1HCAR2KMT2AMAPTF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8044041-B2 e.g. 4-Chloro-1-hydroxy-phthalazine-6-carboxylic acid [4-chloro-3'-(2-dimethylamino-ethoxy)-biphenyl-3-yl]-amide; multifunctioning protein kinase inhibitors; anticarcinogenic, antiinflammatory, antidiabetic agent, neurodegenerative diseases FOREST LABORATORIES HOLDINGS LIMITED (BM) 2011-10-25 — — US claimed
EP-2131656-A2 PHTHALAZINE DERIVATIVES Forest Laboratories Holdings Limited (BM) 2009-12-16 — — EP claimed
US-20080146547-A1 PHTHALAZINE DERIVATIVES FOREST LABORATORIES HOLDINGS LIMITED (BM) 2008-06-19 — — US claimed
WO-2008061108-A2 PHTHALAZINE DERIVATIVES FOREST LABORATORIES HOLDINGS LIMITED (BM) 2008-05-22 — — WO claimed
EP-1042291-B1 ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS KLINGE CO CHEM PHARM FAB (DE) 2005-07-13 — — EP claimed
JP-53025533-A — — None — — JP disclosed
CN-110698328-B Method for using dihydroresveratrol or stilbene derivatives and/or chemical variants thereof as antimicrobial agents 香港浸会大学 2022-12-20 — — CN disclosed
CN-110698328-A Method for using dihydroresveratrol or stilbene derivatives and/or chemical variants thereof as antimicrobial agents 香港浸会大学 2020-01-17 — — CN disclosed
CN-104955332-B The method of preventing and treating arthropod insect 住友化学株式会社 2017-03-29 — — CN disclosed
CN-104461098-A Touch display device and manufacturing method thereof LENOVO BEIJING CO LTD 2015-03-25 — — CN disclosed
WO-2014170343-A1 DEPOLARIZING AGENTS AND NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS FOR TREATING DOPAMINERGIC-RELATED DISORDERS ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE) (FR) 2014-10-23 — — WO disclosed
US-8420684-B2 imidazole derivatives; Alzheimer's Disease, Down syndrome, Huntington's Disease; hypotensive agents; sleeping/eating disorders, anxiolytic agents, antidepressants, antiepileptic agents; drug abuse/withdrawl; 4-Cyclopropylimino-5-(3,4-dihydro-2H-pyran-2-yl)-1-(3-imidazol-1-yl-propyl)-imidazolidin-2-one PROBIODRUG AG (DE) 2013-04-16 — — US disclosed
US-5326869-A Chemical process IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) 1994-07-05 — — US disclosed
US-5294720-A Viricides THE DUPONT MERCK PHARMACEUTICAL CO. (US) 1994-03-15 — — US disclosed
US-4569942-A N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents PFIZER INC. (US) 1986-02-11 — — US disclosed
US-4426524-A Heterocyclic substituted benzyl alcohol, insecticidal ester derivatives, and intermediates FMC CORPORATION (US) 1984-01-17 — — US disclosed
US-4426524-A Heterocyclic substituted benzyl alcohol, insecticidal ester derivatives, and intermediates FMC CORPORATION (US) 1984-01-17 — — US disclosed
US-4415566-A ANTIBIOTICS; BACTERIOSTATS; BACTERICIDES BOEHRINGER INGELHEIM GMBH (DE) 1983-11-15 — — US disclosed
JP-S5325533-A NOVEL PHENYLACETIC ACID DERIVATIVES HISAMITSU PHARMACEUT CO INC 1978-03-09 — — JP disclosed
JP-S05325533-A — — 0001-01-01 — — JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080146547-A1 PHTHALAZINE DERIVATIVES CDK5, HIPK2, PACSIN2 ALDH1A1 3613/4885HCAR2 2014/4885KMT2A 502/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.