Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CDC42 | P60953 | 1/20 | 0.45 |
| ▸ | RAC1 | P63000 | 1/20 | 0.45 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9499453 | 0.88 | SMN1; SMN2 (0.45) | KDM4EL3MBTL1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6074279 | 0.84 | BRPF1 (0.59) | KDM4EL3MBTL1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4049057 | 0.77 | GRIK1 (0.55) | KDM4ESMN1; SMN2GSTP1HTR2CMTNR1A | |
| SCHEMBL9494686 | 0.77 | RXFP1 (0.50) | KDM4EALDH1A1CYP1A2CYP2A6HTR2C | |
| SCHEMBL8463444 | 0.76 | KDM4E (0.44) | KDM4EL3MBTL1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9497513 | 0.76 | LCK (0.48) | KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL8368861 | 0.75 | PTGS1 (0.50) | KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL9156616 | 0.74 | POLB (0.51) | KDM4EL3MBTL1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8366395 | 0.74 | MAPT (0.52) | KDM4EL3MBTL1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL2797929 | 0.73 | KMT2A (0.48) | L3MBTL1ALDH1A1HPGDSMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0240859-B1 | LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1993-04-28 | — | — | EP | disclosed |
| US-4761403-A | QUINOLONE DERIVATIVES | ABBOTT LABORATORIES (US) | 1988-08-02 | — | — | US | disclosed |
| EP-0240859-A2 | Lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1987-10-14 | — | — | EP | disclosed |