Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.37 |
| ▸ | ALDH1B1 | P30837 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9334566 | 0.98 | AKR1B1 (0.42) | AKR1B1HPGDSMN1; SMN2NPSR1GAA | |
| SCHEMBL14588431 | 0.89 | HPGD (0.45) | HPGDSMN1; SMN2NPSR1GAAKMT2A | |
| SCHEMBL9333747 | 0.84 | ALDH2 (0.41) | AKR1B1HPGDSMN1; SMN2NPSR1GAA | |
| SCHEMBL9334571 | 0.84 | LMNA (0.43) | AKR1B1HPGDSMN1; SMN2NPSR1GAA | |
| Hydrochloric Acid SCHEMBL9870305 | 0.82 | AKR1B1 (0.51) | AKR1B1HPGDSMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL14608523 | 0.78 | HPGD (0.47) | HPGDSMN1; SMN2NPSR1GAAKMT2A | |
| SCHEMBL9499446 | 0.77 | HTT (0.36) | AKR1B1HPGDSMN1; SMN2NPSR1GAA | |
| SCHEMBL6522524 | 0.77 | L3MBTL1 (0.56) | AKR1B1HPGDSMN1; SMN2NPSR1KMT2A | |
| SCHEMBL30800673 | 0.76 | STS (0.55) | AKR1B1HPGDGAAKMT2ALMNA | |
| SCHEMBL14620527 | 0.76 | HPGD (0.43) | HPGDSMN1; SMN2NPSR1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5185452-A | Antidiabetic agents; aldose reductase inhibitor | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-02-09 | — | — | US | disclosed |