Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9333747 | 0.80 | ALDH2 (0.41) | SMN1; SMN2GAANPSR1ALDH1A1MAPT | |
| SCHEMBL9334571 | 0.77 | LMNA (0.43) | SMN1; SMN2GAANPSR1ALDH1A1MAPT | |
| SCHEMBL9499154 | 0.77 | AKR1B1 (0.43) | HTTSMN1; SMN2GAANPSR1ALDH1A1 | |
| SCHEMBL9334566 | 0.76 | AKR1B1 (0.42) | HTTSMN1; SMN2GAANPSR1ALDH1A1 | |
| SCHEMBL11233028 | 0.75 | KDM1A (0.53) | HTTALDH1A1MAPTKDM1ALMNA | |
| SCHEMBL11228880 | 0.67 | SMN1; SMN2 (0.67) | SMN1; SMN2GAAALDH1A1MAPTHPGD | |
| SCHEMBL30901818 | 0.67 | KMT2A (0.60) | SMN1; SMN2MAPTTP53LMNAKDM4E | |
| SCHEMBL14588431 | 0.66 | HPGD (0.45) | HTTSMN1; SMN2GAANPSR1ALDH1A1 | |
| SCHEMBL9711140 | 0.66 | ALDH1A1 (0.55) | GAAALDH1A1MAPTAKR1B1LMNA | |
| SCHEMBL9740784 | 0.65 | TSHR (0.43) | SMN1; SMN2ALDH1A1MAPTAKR1B1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5185452-A | Antidiabetic agents; aldose reductase inhibitor | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-02-09 | — | — | US | disclosed |
| EP-0409949-A1 | ARYLSULPHONYL-NITROMETHANES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS. | ICI PLC (GB) | 1991-01-30 | — | — | EP | disclosed |
| WO-1990008763-A1 | ARYLSULPHONYL-NITROMETHANES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-08-09 | — | — | WO | disclosed |