Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9499199 | 1.00 | GAA (0.39) | GAASMN1; SMN2SRCLMNAKDM4E | |
| Iodide SCHEMBL9497223 | 0.80 | GAA (0.57) | GAASMN1; SMN2LMNAKDM4EACHE | |
| Iodide SCHEMBL9497216 | 0.80 | GAA (0.57) | GAASMN1; SMN2LMNAKDM4EACHE | |
| Iodide SCHEMBL9501338 | 0.78 | HDAC8 (0.52) | SRCAPOBEC3AAPOBEC3G | |
| Iodide SCHEMBL9501333 | 0.78 | HDAC8 (0.52) | SRCAPOBEC3AAPOBEC3G | |
| SCHEMBL13822483 | 0.72 | HDAC8 (0.57) | GAASMN1; SMN2KDM4EPKMAPOBEC3A | |
| SCHEMBL6651005 | 0.69 | GAA (0.43) | GAASMN1; SMN2LMNAACHE | |
| SCHEMBL113602 | 0.68 | LMNA (0.52) | GAASMN1; SMN2SRCLMNAPPARG | |
| SCHEMBL113601 | 0.68 | LMNA (0.52) | GAASMN1; SMN2SRCLMNAPPARG | |
| SCHEMBL10797604 | 0.68 | LMNA (0.52) | GAASMN1; SMN2SRCLMNAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0271798-B1 | O-SUBSTITUTED TETRAHYDROPYRIDINE OXIME CHOLINERGIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-04-07 | — | — | EP | disclosed |
| US-4786648-A | ANALGESIC | WARNER-LAMBERT COMPANY (US) | 1988-11-22 | — | — | US | disclosed |
| EP-0271798-A2 | O-Substituted tetrahydropyridine oxime cholinergic agents | WARNER-LAMBERT COMPANY (US) | 1988-06-22 | — | — | EP | disclosed |