Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 2/20 | 0.36 |
| ▸ | DDO | Q99489 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9502885 | 0.94 | PDE2A (0.42) | DAODDOGPR35PDE2APDE1A | |
| SCHEMBL9501069 | 0.91 | DAO (0.40) | PLA2G2ADAODDOGRIN1GRIN2A | |
| SCHEMBL9452197 | 0.80 | GPR35 (0.50) | GPR35PDE2APDE1APDE1BPDE1C | |
| SCHEMBL9499661 | 0.78 | IMPDH2 (0.40) | GPR35GRIN1GRIN2AMEN1KMT2A | |
| SCHEMBL9500387 | 0.77 | FEN1 (0.43) | DAODDO | |
| SCHEMBL9500319 | 0.76 | CDK1 (0.37) | DAOKMT2A | |
| SCHEMBL9452236 | 0.76 | KDM4E (0.49) | MEN1KMT2A | |
| SCHEMBL9389414 | 0.76 | DAO (0.58) | DAODDOGRIN1GRIN2A | |
| SCHEMBL9452264 | 0.75 | GPR35 (0.58) | GPR35PDE2APDE1APDE1BPDE1C | |
| SCHEMBL9500993 | 0.75 | KDM4E (0.37) | GPR35PDE2APDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0303387-B1 | KYNURENIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS | MERCK SHARP & DOHME LTD. (GB) | 1993-04-21 | — | — | EP | claimed |