Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 3/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | BID | P55957 | 3/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.36 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.36 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.36 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.36 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.36 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | CTSV | O60911 | 2/20 | 0.35 |
| ▸ | CTSL | P07711 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9499677 | 0.94 | PLA2G2A (0.38) | PDE2APDE1APDE1BPDE1CGPR35 | |
| SCHEMBL9501069 | 0.90 | DAO (0.40) | DAODDO | |
| SCHEMBL9452264 | 0.82 | GPR35 (0.58) | PDE2APDE1APDE1BPDE1CGPR35 | |
| SCHEMBL9452189 | 0.78 | KDM4E (0.47) | PDE2APDE1APDE1BPDE1CGPR35 | |
| SCHEMBL9499661 | 0.77 | IMPDH2 (0.40) | GPR35MCL1KDM4EALDH1A1HPGD | |
| SCHEMBL9500387 | 0.76 | FEN1 (0.43) | DAODDO | |
| SCHEMBL9500319 | 0.75 | CDK1 (0.37) | DAO | |
| SCHEMBL9452197 | 0.74 | GPR35 (0.50) | PDE2APDE1APDE1BPDE1CGPR35 | |
| SCHEMBL9500993 | 0.74 | KDM4E (0.37) | PDE2APDE1APDE1BPDE1CGPR35 | |
| SCHEMBL9502841 | 0.73 | CTSV (0.46) | PPARAPPARGCTSVCTSLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0303387-B1 | KYNURENIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS | MERCK SHARP & DOHME LTD. (GB) | 1993-04-21 | — | — | EP | claimed |