SCHEMBL9501092

SCHEMBL9501092

CC(C)=CC[SiH2]c1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.36
ABCB11 O95342 1/20 0.36
PTGS1 P23219 1/20 0.36
MEN1 O00255 4/20 0.33
KMT2A Q03164 4/20 0.33
ALDH1A1 P00352 2/20 0.33
TSHR P16473 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
MAPT P10636 3/20 0.33
DHODH Q02127 2/20 0.33
KDM4E B2RXH2 2/20 0.33
TP53 P04637 1/20 0.33
CYP3A4 P08684 1/20 0.33
PKM P14618 1/20 0.33
CDC25A P30304 1/20 0.33
CDC25B P30305 1/20 0.33
RPS6KA3 P51812 1/20 0.33
GLO1 Q04760 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
GPR35 Q9HC97 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31503143 0.89
SCHEMBL31503142 0.85 XPO1 (0.33) XPO1
SCHEMBL31503144 0.80 DHODH (0.36) LMNAABCB11PTGS1MEN1KMT2A
SCHEMBL31503141 0.80 DHODH (0.36) LMNAABCB11PTGS1MEN1KMT2A
SCHEMBL9651826 0.76 HTT (0.30) HTT
SCHEMBL9651773 0.76 ALDH1A1 (0.41) ALDH1A1TSHRHIF1A
SCHEMBL9441984 0.71 MAOB (0.32)
SCHEMBL9717044 0.71 MAOB (0.32)
SCHEMBL463323 0.70 ALDH1A1 (0.36) ALDH1A1TSHRCYP2C19HTT
SCHEMBL700561 0.69 ABCB11 (0.33) LMNAABCB11PTGS1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0375079-B1 ALKENYLPHOXYLIMIDE MODIFIED POLYIMIDE Technochemie GmbH - Verfahrenstechnik (DE) 1993-06-09 EP disclosed
US-5120824-A Molding materials based on unsaturated monomers containing imide groups; engineering thermoplastics; toughness; heat resistance TECHNOCHEMIE GMBH VERFAHRENSTECHNIK (DE) 1992-06-09 US disclosed
EP-0469684-A1 Polyimide compositions SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1992-02-05 EP disclosed
US-4981934-A Curable composition comprising bis-imide and bis-(alkenyl phenol) TECHNOCHEMIE GMBH VERFAHRENSTECHNIK (DE) 1991-01-01 US disclosed
EP-0375079-A2 Alkenylphoxylimide modified polyimide Technochemie GmbH - Verfahrenstechnik (DE) 1990-06-27 EP disclosed
EP-0355926-A2 Alkenyl-modified polyimides Technochemie GmbH - Verfahrenstechnik (DE) 1990-02-28 EP disclosed
US-4035345-A Thermosetting bis-imide compositions RHONE-POULENC S.A. (FR) 1977-07-12 US disclosed