SCHEMBL9501405

SCHEMBL9501405

CCOC(=O)C(NC(=O)CS(=O)(=O)Nc1ccc(F)cc1C(F)(F)F)C(C)O

nearest known ligand 0.41

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.41
EPHX2 P34913 1/20 0.38
PPARG P37231 1/20 0.38
MRGPRX1 Q96LB2 7/20 0.38
ALDH1A1 P00352 2/20 0.34
NPC1 O15118 1/20 0.34
HTT P42858 1/20 0.34
RAB9A P51151 1/20 0.34
PAX8 Q06710 1/20 0.34
AR P10275 1/20 0.34
NR3C2 P08235 2/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
TLR4 O00206 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9501345 0.90 EPHX2 (0.37) KMT2AEPHX2PPARGMRGPRX1ALDH1A1
SCHEMBL9502967 0.89 KMT2A (0.43) KMT2AEPHX2PPARGMRGPRX1ALDH1A1
SCHEMBL9363823 0.88 KMT2A (0.44) KMT2AEPHX2PPARGMRGPRX1ALDH1A1
SCHEMBL9499252 0.82 SLC22A12 (0.39) EPHX2AR
SCHEMBL9499710 0.81 KMT2A (0.45) KMT2AEPHX2PPARGMRGPRX1ALDH1A1
SCHEMBL9499692 0.81 TSHR (0.44) KMT2AEPHX2PPARGMRGPRX1ALDH1A1
SCHEMBL9363652 0.80 KMT2A (0.46) KMT2AEPHX2PPARGMRGPRX1ALDH1A1
SCHEMBL9500279 0.80 KMT2A (0.44) KMT2AEPHX2PPARGMRGPRX1AR
SCHEMBL9501500 0.79 EPHX2 (0.38) KMT2AEPHX2PPARGMRGPRX1ALDH1A1
SCHEMBL9363404 0.78 KMT2A (0.42) KMT2AEPHX2PPARGMRGPRX1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5210290-A NMR diagnostic aid SCHERING AKTIENGESELLSCHAFT (DE) 1993-05-11 US disclosed