Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1657163 | 0.92 | MMP8 (0.56) | MMP8NPC1MEN1KMT2APTGS2 | |
| SCHEMBL266419 | 0.89 | MMP8 (0.74) | MMP8NPC1MEN1KMT2APIN1 | |
| SCHEMBL28674585 | 0.87 | MMP8 (0.72) | MMP8NPC1MEN1KMT2APIN1 | |
| SCHEMBL31069943 | 0.87 | MMP8 (0.72) | MMP8NPC1MEN1KMT2APIN1 | |
| SCHEMBL271585 | 0.87 | MMP8 (0.59) | MMP8NPC1MEN1KMT2APIN1 | |
| SCHEMBL13009601 | 0.84 | LMNA (0.51) | MMP8NPC1MEN1KMT2ATSHR | |
| SCHEMBL11833508 | 0.84 | PTGS2 (0.49) | MMP8NPC1MEN1KMT2APTGS2 | |
| SCHEMBL28474562 | 0.84 | MMP8 (0.73) | MMP8NPC1MEN1KMT2APIN1 | |
| SCHEMBL11729113 | 0.83 | PTGS2 (0.47) | MMP8NPC1MEN1KMT2APTGS2 | |
| SCHEMBL11850461 | 0.83 | PTGS2 (0.47) | MMP8NPC1MEN1KMT2APTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |