Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9303635 | 0.90 | LMNA (0.59) | HTTALDH1A1LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL9302400 | 0.85 | ALDH1A1 (0.53) | HTTALDH1A1LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL9302427 | 0.79 | ALDH1A1 (0.53) | HTTALDH1A1LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL8129105 | 0.78 | HDAC1 (0.56) | HTTALDH1A1SMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL9302805 | 0.78 | TNF (0.53) | HTTALDH1A1SMN1; SMN2TSHRMAPK1 | |
| SCHEMBL5960056 | 0.78 | HTT (1.00) | HTTALDH1A1LMNACYP19A1SMN1; SMN2 | |
| SCHEMBL9299036 | 0.77 | TNF (0.55) | ALDH1A1LMNACYP1A2CYP2C19POLB | |
| SCHEMBL5960103 | 0.77 | ALDH1A1 (0.79) | HTTALDH1A1LMNASMN1; SMN2TSHR | |
| SCHEMBL9304259 | 0.76 | GALR3 (0.69) | ALDH1A1MAPK1 | |
| SCHEMBL8137536 | 0.76 | TNF (0.59) | HTTALDH1A1LMNACYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0543861-A1 | IMIDAZOPYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1993-06-02 | — | — | EP | claimed |
| WO-1992003422-A1 | BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1992-03-05 | — | — | WO | claimed |
| EP-0543861-A1 | IMIDAZOPYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1993-06-02 | — | — | EP | disclosed |
| US-5180723-A | Hypertensives, bronchodilators, antiedemic agents | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1993-01-19 | — | — | US | disclosed |
| WO-1992003422-A1 | BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1992-03-05 | — | — | WO | disclosed |