Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | F2R | P25116 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9504743 | 0.89 | NPSR1 (0.47) | NPSR1SMN1; SMN2KMT2ALMNAMAPT | |
| SCHEMBL9503597 | 0.84 | NPSR1 (0.44) | NPSR1SMN1; SMN2PPARG | |
| SCHEMBL9506003 | 0.74 | GLA (0.38) | KMT2AALDH1A1POLBMEN1TSHR | |
| SCHEMBL9503685 | 0.73 | HDAC6 (0.54) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1742555 | 0.72 | ALDH1A1 (0.58) | NPSR1SMN1; SMN2KMT2AMAPTALDH1A1 | |
| SCHEMBL2673432 | 0.70 | NPSR1 (0.49) | NPSR1SMN1; SMN2KMT2ALMNAMAPT | |
| SCHEMBL13671436 | 0.69 | KMT2A (0.52) | NPSR1SMN1; SMN2KMT2ALMNAMAPT | |
| SCHEMBL4129269 | 0.69 | MAPK1 (0.62) | SMN1; SMN2LMNAMAPTMAPK1ALDH1A1 | |
| SCHEMBL30802675 | 0.69 | KDM4E (0.62) | SMN1; SMN2KMT2APOLBMEN1RAB9A | |
| Fluoride SCHEMBL11788893 | 0.69 | NPSR1 (0.48) | NPSR1SMN1; SMN2KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0550574-A1 | HETEROCYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-07-14 | — | — | EP | disclosed |
| WO-1992005180-A1 | HETEROCYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-04-02 | — | — | WO | disclosed |