SCHEMBL950309

SCHEMBL950309

O=C(O)c1cc(Br)cn1-c1ccncc1Cl

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR1 Q9BXC0 1/20 0.39
MCL1 Q07820 1/20 0.35
CCNC P24863 2/20 0.35
CDK8 P49336 2/20 0.35
HASPIN Q8TF76 1/20 0.35
CDK19 Q9BWU1 1/20 0.35
GAA P10253 1/20 0.34
KMT2A Q03164 4/20 0.33
MEN1 O00255 3/20 0.33
CTDSP1 Q9GZU7 1/20 0.33
GABRA2 P47869 3/20 0.33
GABRB2 P47870 3/20 0.33
CAPN1 P07384 1/20 0.33
KDM4E B2RXH2 3/20 0.32
MAPK1 P28482 1/20 0.32
HTT P42858 1/20 0.32
POLB P06746 1/20 0.32
HCAR2 Q8TDS4 1/20 0.32
LMNA P02545 1/20 0.32
BCL2A1 Q16548 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12528807 0.88 HCAR1 (0.38) HCAR1CCNCCDK8GAAKMT2A
SCHEMBL950692 0.80 HCAR2 (0.39) MCL1CCNCCDK8HTTPOLB
SCHEMBL950635 0.76 HCAR1 (0.39) HCAR1GAAHTTBCL2A1ALDH1A1
SCHEMBL951594 0.75 LMNA (0.44) MCL1GAAKMT2AMEN1KDM4E
SCHEMBL4669858 0.74 NOTUM (0.45) HCAR1MCL1
SCHEMBL951639 0.72 MALT1 (0.38) MCL1LMNASMN1; SMN2
SCHEMBL15051322 0.72 ALDH1A1 (0.45) GAAKMT2AMEN1MAPK1LMNA
SCHEMBL15051320 0.72 ALDH1A1 (0.45) GAAKMT2AMEN1MAPK1LMNA
SCHEMBL951326 0.72 NOTUM (0.41) MCL1POLBALDH1A1
SCHEMBL4538521 0.70 MAPT (0.35) MCL1KMT2AMEN1GABRA2GABRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101287721-B Hydrazide compound and pesticidal use of the same SUMITOMO CO LTD 2013-03-27 CN disclosed
US-7968573-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-28 US disclosed
EP-1937664-B1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2011-06-15 EP disclosed
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME IKEGAMI HIROSHI 2011-03-24 US disclosed
US-7867949-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-11 US disclosed
EP-2251336-A1 Hydrazide compounds as intermediates of pesticides Sumitomo Chemical Company, Limited (JP) 2010-11-17 EP disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 US disclosed
CN-101287721-A Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL CO (JP) 2008-10-15 CN disclosed
EP-1937664-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME Sumitomo Chemical Company, Limited (JP) 2008-07-02 EP disclosed
WO-2007043677-A9 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2007-06-07 WO disclosed
WO-2007043677-A9 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2007-06-07 WO disclosed
WO-2007043677-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-04-19 WO disclosed
WO-2007043677-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-04-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, H1-2, H1-0 HCAR1 1094/4885MCL1 2288/4885CCNC 2802/4885
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same ACHE, DDT, CAT HCAR1 1415/4885MCL1 2297/4885CCNC 4521/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.