Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 2/20 | 0.58 |
| ▸ | DRD2 | P14416 | 9/20 | 0.51 |
| ▸ | DRD3 | P35462 | 9/20 | 0.51 |
| ▸ | DRD4 | P21917 | 5/20 | 0.49 |
| ▸ | HTR1A | P08908 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | DRD5 | P21918 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9504458 | 0.91 | FYN (0.62) | FYNDRD2DRD3DRD4HTR1A | |
| SCHEMBL9504552 | 0.86 | DRD2 (0.61) | DRD2DRD3DRD4HTR1AADRB2 | |
| SCHEMBL9507115 | 0.82 | DRD2 (0.70) | DRD2DRD3DRD4HTR1AADRB2 | |
| Hydrochloric Acid SCHEMBL9504453 | 0.81 | DRD2 (0.69) | DRD2DRD3DRD4HTR1AADRB2 | |
| SCHEMBL9507046 | 0.78 | DRD2 (0.55) | FYNDRD2DRD3DRD4HTR1A | |
| SCHEMBL9504432 | 0.77 | ADRA2A (0.44) | FYN | |
| SCHEMBL9504450 | 0.77 | DRD2 (0.54) | DRD2DRD3DRD4HTR1AADRB2 | |
| Hydrochloric Acid SCHEMBL9503363 | 0.76 | ADRA2A (0.43) | FYN | |
| Hydrochloric Acid SCHEMBL9507124 | 0.76 | DRD2 (0.55) | DRD2DRD3DRD4HTR1AADRB2 | |
| SCHEMBL10606282 | 0.75 | FYN (1.00) | FYNDRD2DRD3DRD4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0321968-B1 | COMPOUNDS ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.p.A. (IT) | 1993-07-28 | — | — | EP | disclosed |
| US-5151414-A | Hypotensive agents | SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) | 1992-09-29 | — | — | US | disclosed |
| US-5070106-A | HYPOTENSIVES, CEREBRAL DISORDERS | SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) | 1991-12-03 | — | — | US | disclosed |
| EP-0321968-A2 | Compounds active on the cardiovascular system | ZAMBON GROUP S.p.A. (IT) | 1989-06-28 | — | — | EP | disclosed |