Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 6/20 | 0.44 |
| ▸ | DRD4 | P21917 | 5/20 | 0.44 |
| ▸ | DRD3 | P35462 | 4/20 | 0.44 |
| ▸ | UBLCP1 | Q8WVY7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9503346 | 0.89 | CA1 (0.41) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL9506542 | 0.88 | CA1 (0.41) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL9503561 | 0.76 | CA1 (0.43) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL9503507 | 0.76 | TAS1R3 (0.43) | MTNR1AMTNR1BCA1CA2ADRA1D | |
| SCHEMBL9506501 | 0.75 | CA1 (0.42) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL7333054 | 0.69 | MTNR1A (0.63) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL7333056 | 0.69 | MTNR1A (0.63) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL30089783 | 0.68 | MTNR1A (0.84) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL2597485 | 0.68 | MTNR1A (0.84) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL2351965 | 0.68 | MTNR1A (0.84) | MTNR1AMTNR1BCA1CA2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0321968-B1 | COMPOUNDS ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.p.A. (IT) | 1993-07-28 | — | — | EP | disclosed |
| US-5151414-A | Hypotensive agents | SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) | 1992-09-29 | — | — | US | disclosed |
| US-5070106-A | HYPOTENSIVES, CEREBRAL DISORDERS | SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) | 1991-12-03 | — | — | US | disclosed |
| EP-0321968-A2 | Compounds active on the cardiovascular system | ZAMBON GROUP S.p.A. (IT) | 1989-06-28 | — | — | EP | disclosed |